We are seeking an individual with antibody discovery and engineering experience. The candidate will be a key contributor in developing antibody-based therapeutics to advance the pipeline within QLSF.

RESPONSIBILITIES

• Advance and improve multi-specific antibody therapeutics selectivity, potency and developability.
• Design and optimize antibody display libraries.
• Molecular cloning, hybridoma sequencing, sequence analysis, and generating recombinant antibody expression constructs.
• Think creatively to generate best-in-class therapeutic leads.
• Provide scientific and technical input to guide pipeline development.
• Work on multiple protein engineering projects simultaneously and deliver results in a timely manner.

REQUIREMENTS

• Ph.D. in immunology, molecular biology, cell biology, or biochemistry.
• 5-10 years experience working in a biotechnology or academic setting focusing on and overseeing discovery, design and antibody engineering using multi-platform technologies.
• Deep understanding of antibody structure and biology to generate well-behaved, potent antibody therapeutic leads.
• Appropriate skills in antibody characterization including kinetic binding and thermal stability.
• Candidates with structural biology and protein modeling is a plus.
• Humanization of antibody variable domains is a plus.
• Excellent organization skills, planning and record keeping.
• Strong motivation with a dedicated work ethic
• Evidence of creative problem-solving skills and ability to take on difficult research challenges
• Excellent oral presentation and communication skills
• Excellent team player, capable of thriving in a fast paced, highly collaborative, dynamic work environment.

QLSF Biotherapeutics offers a comprehensive and competitive compensation package, including paid time off, medical, dental, and vision insurance, as well as a 401(k)-retirement savings plan.

Principals only. Recruiters, please don’t contact this job poster.

Do NOT contact us with unsolicited services or offers

We are seeking individual(s) with protein production, purification, and analytical characterization experiences, capable of advancing our pipeline in both drug discovery and development projects. The candidate will be a key contributor in providing oversight for protein science activities for pipeline projects within QLSF Biotherapeutics. The position requires in-depth and hands-on knowledge of protein production, purification, and characterization. Position/Title commensurate with education and experience.

RESPONSIBILITIES

• Mammalian protein production from scalable transient transfection, through cell harvest, using vacuum and/or depth filtering. Aseptic techniques is a must.
• High throughput antibody/protein purification using Protein A/G Affinity and other polishing chromatography (IEX, HIC, CEX, SEC, RP) techniques is preferable.
• Operation and maintaining AKTA chromatographic systems, Agilent HPLC systems, and single use wave bag system (GE/Sartorius).
• Antibody/protein characterizations using various analytical techniques, such as HPLC-SEC, HPLC-CIEX, SDS-PAGE, spectroscopy, and protein-protein interaction (Biacore/Fortebio). Experience in DSF, differential light scattering, and mass spectrometer is a plus.
• Develop and optimize monoclonal and multi-specific antibody production and purification.

REQUIREMENTS

• B.S./ M.S./ Ph.D. in immunology, molecular biology, cell biology, biochemistry, chemical engineering, or other relevant life science disciplines with lab experience. Preferred candidates will have experience working as a scientist or research associate in biotech companies
• Experience in high throughput transient transfections, filtrations, chromatography by various separation techniques, and analytical characterizations.
• Execute sound judgment as defined current practices for appropriate actions, understand technical literature for troubleshooting, and demonstrated ability to multitasks and prioritize.
• Be a good team player and work collaboratively with other scientists.

QLSF Biotherapeutics offers a comprehensive and competitive compensation package, including stock options, paid time off, medical, and 401(k)-retirement savings plan.

The preferred candidate will have deep knowledge in immunology or cancer research with extensive hands-on experience in biotherapeutic discovery and target validation. The candidate will the knowledge and skills to explore immuno-oncology modulatory proteins using cutting edge immunological methods. Position/Title commensurate with education and experience.

RESPONSIBILITIES

• Quickly advance discovery research programs to identify and validate novel immuno-oncology biotherapeutics, focusing on effector cell engagers and other therapies capable of immune-mediated tumor cell killing
• Work independently on the design, execution, and interpretation of experiments
• Work closely with a highly productive team of research associates and/or scientists to initiate and rapidly to advance new therapeutic programs
• Identify and adopt in vitro and in vivo methods to facilitate target discovery and elucidate the mechanism(s) of action
• Evaluate new technologies and develop assays to advance and accelerate discovery programs
• Work cross-functionally with colleagues in protein engineering, in vivo biology, and external collaborations
• Attend team meetings and deliver clear and well-prepared presentations. Be an active participant in discussions
• Stay abreast of latest scientific and technology advancements in the field
• Provide scientific and technical input to lead pipeline development

REQUIREMENTS

• Experience in biotherapeutic target evaluation, validation and candidate selection
• Skilled in designing pre-clinical in vivo experiments to assess drug candidate efficacy
• Extensive hands-on experience in basic immunology techniques including flow cytometry, cytokine analysis, cytotoxicity, proliferation assays, and immune cell isolation etc.
• Skill in mammalian tissue culture techniques for cell lines and primary cells, generation and maintenance of transfected cells
• A background in immuno-oncology drug discovery, particularly in targeting tumor stroma and immune cell composition as demonstrated by peer reviewed publications and/or patent submissions
• Previous experience in antibody drug discovery is a plus
• Strong motivation with a dedicated work ethic
• Evidence of creative problem-solving skills and ability to take on difficult research challenges
• Excellent oral presentation and communication skills
• Team player able to work in a cross-functional environment

QLSF Biotherapeutics offers a comprehensive and competitive compensation package, including paid time off, medical, dental, and vision insurance, as well as a 401(k)-retirement savings plan.

Principals only. Recruiters, please don’t contact this job poster.

do NOT contact us with unsolicited services or offer