We are seeking individual(s) with antibody discovery and engineering experiences, capable of advancing our pipeline in both drug discovery and development projects. The candidate will be a key contributor in providing oversight for antibody engineering activities for pipeline projects within QLSF Biotherapeutics. Position/Title commensurate with education and experience.

RESPONSIBILITIES

• Expertise in multi-specific antibody platforms, Fc engineering, and developability.
• Think creatively to generate best-in-class therapeutic leads.
• Provide scientific and technical input to guide pipeline development.
• Work on multiple protein engineering projects simultaneously and deliver results in a timely manner.

REQUIREMENTS

• Ph.D. in immunology, molecular biology, cell biology, or biochemistry with lab experience. Preferred candidates will have therapeutic discovery experience in the biotech industry.
• Deep understanding of antibody structure and biology to generate well-behaved, potent antibody therapeutic leads.
• Appropriate skills include molecular cloning, hybridoma sequencing, sequence analysis, and recombinant antibody expression constructs.
• Appropriate skills in antibody characterization including kinetic binding and thermal stability.
• Excellent team player, capable of thriving in a fast paced, highly collaborative, dynamic work environment.
• Excellent organization skills, planning and record keeping.
• Candidates with structural biology and protein modeling is a plus.
• Humanization of antibody variable domains is a plus.

QLSF Biotherapeutics offers a comprehensive and competitive compensation package, including stock options, paid time off, medical, and 401(k)-retirement savings plan.

We are seeking individual(s) with protein production, purification, and analytical characterization experiences, capable of advancing our pipeline in both drug discovery and development projects. The candidate will be a key contributor in providing oversight for protein science activities for pipeline projects within QLSF Biotherapeutics. The position requires in-depth and hands-on knowledge of protein production, purification, and characterization. Position/Title commensurate with education and experience.

RESPONSIBILITIES

• Mammalian protein production from scalable transient transfection, through cell harvest, using vacuum and/or depth filtering. Aseptic techniques is a must.
• High throughput antibody/protein purification using Protein A/G Affinity and other polishing chromatography (IEX, HIC, CEX, SEC, RP) techniques is preferable.
• Operation and maintaining AKTA chromatographic systems, Agilent HPLC systems, and single use wave bag system (GE/Sartorius).
• Antibody/protein characterizations using various analytical techniques, such as HPLC-SEC, HPLC-CIEX, SDS-PAGE, spectroscopy, and protein-protein interaction (Biacore/Fortebio). Experience in DSF, differential light scattering, and mass spectrometer is a plus.
• Develop and optimize monoclonal and multi-specific antibody production and purification.

REQUIREMENTS

• B.S./ M.S./ Ph.D. in immunology, molecular biology, cell biology, biochemistry, chemical engineering, or other relevant life science disciplines with lab experience. Preferred candidates will have experience working as a scientist or research associate in biotech companies
• Experience in high throughput transient transfections, filtrations, chromatography by various separation techniques, and analytical characterizations.
• Execute sound judgment as defined current practices for appropriate actions, understand technical literature for troubleshooting, and demonstrated ability to multitasks and prioritize.
• Be a good team player and work collaboratively with other scientists.

QLSF Biotherapeutics offers a comprehensive and competitive compensation package, including stock options, paid time off, medical, and 401(k)-retirement savings plan.

We are expanding our teams with multiple positions to support immuno-oncology experiments in vitro and in vivo.  The preferred candidate will have deep knowledge in immunology or cancer research with extensive hands-on experience in biotherapeutic discovery and target validation.  Position/Title commensurate with education and experience.

RESPONSIBILITIES

• Work independently on the design, execution, and interpretation of experiments.
• Identify and adopt in vitro and in vivo methods to facilitate target discovery and elucidate the mechanism(s) of action.
• Attend team meetings and deliver clear and well-prepared presentations. Be an active participant in discussions.
• Stay abreast of latest scientific and technology advancements in the field.
• As a director to lead the biology group, provide scientific and technical input to lead pipeline development.

REQUIREMENTS

• In vivo experimental design, rodent handing, dosing, analysis and tissue processing.
• Extensive hands-on experience in basic immunology techniques including flow cytometry, cytokine analysis, cytotoxicity and proliferation assays, etc.
• Mammalian tissue culture techniques for cell lines and primary cells, generation and maintenance of transfected cells.
• Previous experience in antibody drug discovery is a plus.
• Strong motivation with a dedicated work ethic.
• Excellent oral presentation and communication skills.
• Team player

QLSF Biotherapeutics offers a comprehensive and competitive compensation package, including stock options, paid time off, medical, and 401(k)-retirement savings plan.

We are expanding our team with multiple positions to support discovery research of next generation antibody-based therapeutics.  Position/Title commensurate with education and experience.

RESPONSIBILITIES

• Plan, design and execute mouse tumor models (syngeneic, xenograft, orthotopic) evaluating anti-tumor activity of protein-based drugs.
• Perform in vivo procedures in mice including drug administration (IP, IV, SC and oral), bleeding, tissue collection, and processing of multiple tissues.
• Ex vivo analysis of immune cells including T cell and myeloid cell phenotype and functionality using FACS, ELISA and other relevant assays.
• Culture primary and immortalized cells.
• Data collection, analysis, interpretation and presentation.
• Manage vivarium and maintain regulatory requirement.

QUALIFICATIONS

• B.S. / M.S. / PhD in immunology, biochemistry, or other relevant life science disciplines with laboratory experience in an academic, biotechnology, or pharmaceutical setting.
• Experience working with preclinical tumor models, including mouse handling, dosing, tumor cell implantation, tumor growth analysis and tissue collection techniques.
• Experience with cell culture, immune cell phenotyping and functional analysis.
• Strong attention to detail, analytical, time management, organizational and interpersonal skills.
• Ability to work independently and to handle multiple projects and deadlines in a fast-paced biotech environment.

WORKING SCHEDULE AND PHYSICAL REQUIREMENTS

• Occasional weekend / holiday, and/or evening hours required.

QLSF Biotherapeutics offers a competitive compensation package, including comprehensive benefits, stock options, as well as a 401(k)-retirement savings plan.